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(A) and (B) CαRMSD of MOR and CCR5 showed MCC22 binding reduces the overall conformational flexibility of both MOR and CCR5 in MOR-CCR5 heteromer. (C) and (D) Significant loss of conformational flexibility was observed in the ICL3 region in MOR between TM5 and TM6 as well as in the ECL3 region of CCR5 between TM6 and TM7 due to MCC22 binding.
