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. Author manuscript; available in PMC: 2016 Oct 7.
Published in final edited form as: J Med Chem. 2015 Oct 20;58(21):8647–8657. doi: 10.1021/acs.jmedchem.5b01245

Table 3.

Potency of MCC bivalent ligands relative to a mixture of monovalent mu agonist 4 and CCR5 antagonist 2 in LPS-pretreated mice

Compound Spacer length (atoms) Relative Potencya
3a 14 4.9
3b 17 4.8
3c 19 4.5
3d 21 6.2
3e 22 3,559
3f 24 0.4
2 + 4 1
a

The potencies are relative to the observed ED50 of the mixture (2 + 4) was 52 pmol/mouse (34.6 – 78.2).