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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2016 May 11;15(8):1943–1951. doi: 10.1158/1535-7163.MCT-15-0306

Figure 5.

Figure 5

Mechanism by which infiltrating T cell-enhanced AR expression increases BCa cell invasion. (a) Changes in metastasis related genes after BCa cells were co-cultured with T cells. (b) VEGFa mRNA expression (left panel) and qPCR (right panel) in T24 and J82 cells after co-culture with HH cells. (c) Invasion assay after treatment with VEGFa antagonist in the co-culture system. (d) HIFα expression after AR knockdown in T24 and J82 cells. si-AR, AR siRNA; si-luc, AR luciferase. (e) Impact of AF degradation enhancer ASC-J9® on T cell- induced BCa invasion. (f) HIF-1α expression after over expressing AR (OE-AR). (g-h) After inhibiting HIF-1α using the HIF-1α inhibitor FM-19G11, (g) VEGFa expression and (h) invasion induced by T cells was tested.