Fig 7. Hb/Hp/Hx complexes play a role in the proinflammatory functions of HDL.

HDL was separated from wild-type (WT), Hp−/− and Hx−/− mice either with or without SCD (n = 8 each). (A) The HDL inflammatory index (HII) was measured by monocyte chemotaxis activity (MCA). (B) Proinflammatory HDL (p-HDL) level was measured by plate assay after HDL was isolated by HPLC as previously described. HII<1 and lower p-HDL level were only found in the Hp knock-out SCD mice. Comparisons were performed by ANOVA (* = p<0.05; # = p<0.01).