Alterations in (A) female and (B) male body weight, (C) female and (D) male Kidney weight body weight ratio (KW/BW), (E) female and (F) male serum BUN, and (G) female and (H) male serum CRE in the four rat cohorts. qPCR analysis of (I) female and (J) male renal ngal mRNA levels in the four rat cohorts. Urine Ngal levels of (K) female and (L) males in each cohort. CTL, control; AMK, Aristolochia manshuriensis Kom; OM, omeprazole; O+A, omeprazole and AMK. Data are expressed as mean ± SEM. *P<0.05 vs. CTL cohort; **P<0.01 vs. CTL cohort; ***P<0.001 vs. CTL cohort; # P<0.05 vs. AMK cohort; ## P<0.01 vs. AMK cohort; ### P<0.001 vs. AMK cohort. n = 6~7.