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. Author manuscript; available in PMC: 2016 Oct 7.
Published in final edited form as: Annu Rev Cell Dev Biol. 2016 Aug 1;32:399–409. doi: 10.1146/annurev-cellbio-111315-125134

Table 1.

Metabolic pathways in stem and progenitor cells

Stem/progenitor cell Surrounding environment Key regulators Metabolic pathway
Mesenchymal stem cell Hypoxia Hif-1α Glycolysis
Chondroblast Hypoxia Glycolysis
Osteoblast Not available OXPHOS
Neural stem cell Hypoxia Foxo3 Low glycolysis
Neural progenitor Normoxia Acetyl-CoA transferase Fatty acid synthesis
Hematopoietic stem cell Hypoxia Hif-1α Glycolysis
mTOR Mitochondrial metabolism, ROS
Pml-Pparδ Fatty acid oxidation
Foxo Glycolysis, ROS
Lkb1 Mitochondrial biogenesis
Embryonic stem cell Not applicable Pentose phosphate pathway Glycolysis, low OXPHOS