Table 1.
Mortality among ART-naïve people living with HIV-2
| Author Year | Period Country | Population size | Median age years [IQR] | Women (%) | Initial CD4 median [IQR] | Number of deaths | Mortality rate/100 PY | Mortality hazard ratio | Survival probability | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Van Der Loeff 2002 (25) | 1986–1997 Gambia | 666 HIV-2 | 35 | [16–70] | 60% | 325 [130–590] | 342 | (51.4%) | 22.0 (19.7–24.3) | 0.5 [0.28–0.88] | 57.2% | |
| 746 HIV-1 | 30 | [15–68] | 46% | 210 [70–401] | 423 | (56.7%) | 35.3 (32.0–38.7) | Ref | 48.0% | |||
| 107 HIV-Dual | 32 | [19–72] | 55% | 230 [110–510] | 63 | (58.9%) | 41.7 (31.4–52.0) | 1.27 [0.51–3.7] | 40.3% | |||
| Togun T 2011 (26) | 2004–2009 Gambia | 103 HIV-2 | – | NA | NA | NA | 15 | (14.6%) | 21.9 [18.3–26.2] | 0.73 [0.4–1.2] | NA | |
| 647 HIV-1 | – | NA | NA | NA | 96 | (14.8%) | Ref | NA | ||||
| 40 HIV-Dual | – | NA | NA | NA | 7 | (17.5%) | 1.07 [0.5–2.3] | NA | ||||
| Van Der Loeff 2010 (27) | 1991–2009 Guinea-Bissau | 133 HIV-2 | 47 | [36–60] | 68% | 25 [18–32]$ | 66 | (50%) | 4.5 (3.6, 5.8) | 1.9 (1.3, 2.8) | NA | |
| 158 HIV-neg | 49 | [38–62] | 73% | NA | 49 | (31%) | 2.1 (1.6, 2.9) | Ref | NA | |||
| Tienen C 2011 (28) | 1989–2009 Guinea Bissau | 285 HIV-2 | 44 | [34–58] | 64% | NA | 111 | (39%) | 4.1 [3.4–5.0] | 2.6 [2.1–3.2] | NA | |
| 117 HIV-1 | 31 | [25–42] | 55% | NA | 43 | (40%) | 9.6 [7.1–12.9] | 7.3 [5.3–10.0] | NA | |||
| 53 HIV-Dual | 47 | [35–60] | 86% | NA | 24 | (45%) | 8.8 [4.3–7.9] | 6.6 [4.4–9.9] | NA | |||
| 4,797 HIV-neg | 25 | [20–43] | 58% | NA | 783 | (16%) | 1.6 [5.9–13.1] | Ref | NA | |||
| Gourlay A 2012 (29) | 2003–2010 Guinea Bissau | 146 HIV-2 | 56 | Sd = 15 | 68% | 31 [26–38]$ | 44 | (30%) | 5.7 [4.2–7.6] | 1.9 (1.2–3.1) | NA | |
| 197 HIV-neg | 53 | Sd = 18 | 73% | 40 [36–46]$ | 28 | (14%) | 2.5 [1.7–3.6] | Ref | NA | |||
| Prince PD 2014 (30*) | Gambia Guinea Bissau | 1949 HIV-2 | – | NA | NA | NA | 666 | (34%) | NA | Ref | NA | |
| 1270 HIV-1 | – | NA | NA | NA | 586 | (46%) | NA | 1.9 [1.4–2.4] | NA | |||
HIV-Dual: HIV-1 and HIV-2 dually reactive individuals; HIV-neg: HIV-negative individuals; NA: not available; Ref: reference value; PY: person-years of observation. Sd: standard deviation;
$
: CD4 count expressed in %