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. 2016 Oct 4;54(3):983–993. doi: 10.3233/JAD-160537

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Fig.2 — Optimal temporal order, S^optimal, of the 10 AD biomarkers estimated by the EBP model. A) The y-axis shows the S^optimal and the x-axis shows the CARE index score at which the corresponding event occurred. B) Bootstrap cross-validation of the S^optimal. Each entry in the matrix represents the proportion of the S^optimal during 500 bootstrap samples. The proportion values range from 0 to 1 and correspond to color, from white to black. The CARE index scores with their corresponding biomarkers follow: 1, increased HIP^FCI; 2, decreased PCC^FCI; 3, decreased Aβ concentration; 4, increased p-tau concentration; 5, decreased MMSE score; 6, increased ADAS score; 7, decreased HIP^GMI; 8, decreased AVLT score; 9, decreased FUS^GMI; 10, increased FUS^FCI.