Fig.3.

CARE index associated with AD clinical stages. A) Normalized likelihoods across the CARE index. The cyan, yellow, red, and black lines represent the likelihoods at each score on the CARE index for a CN subject, an EMCI subject, an LMCI subject, and an AD subject, respectively. B) CARE index distribution in CN and AD groups calculated from the EBP model. The CARE index is ordered by the maximum likelihood event sequence. Each score on the CARE index corresponds to the occurrence of a biomarker event. CARE index score 0 corresponds to no events having occurred and CARE index score 10 corresponds to all events having occurred. Both CN and AD groups showed heterogeneous index distributions. C) CARE index distributions in EMCI and LMCI groups. The proportion of EMCI (yellow) and LMCI (red) subjects at each CARE index score was plotted. D) A box plot of the CARE index score differences between groups. The median CARE index scores for CN, EMCI, LMCI, and AD groups are 2, 4, 6, and 9, respectively. The two-sample t-tests between CN and EMCI, CN and LMCI, EMCI and LMCI, and AD and LMCI showed significant differences. The red “+” denotes an outlier in the CN group.