Figure 2.

MERVL-LTR-Driven Transcriptional Network Activated upon iPSC Reprogramming

(A and B) Heatmap showing relative probe-normalized expression levels of MERVL⁺ transcriptional network in early embryos (A) and induced pluripotent stem cell reprogramming (B). MEF, mouse embryonic fibroblasts. Refractory (SSEA1-/Thy1⁺) and poised (SSEA1⁺/Thy1⁻) stages correspond to fluorescence-activated cell sorting (FACS)-sorted cells at day 6, where passage 8 (p8; corresponding to day 21), p12 (corresponding to day 29) iPSCs represent intermediate-late stages of reprogramming and p29 (corresponding to day 60) iPSCs are fully reprogrammed. Scale bar depicts log₂ relative expression. Data are from Park et al. (2015) (A) and (I.M., unpublished data) (B).

See also Figure S2 and Table S4.