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. 2016 Oct 7;198(21):2985–2999. doi: 10.1128/JB.00520-16

TABLE 3.

AphA ChIP-seq data

Gene IDa Annotation AphA box-like sequence Avg fold enrichment Microarray (V. harveyi)b P value
VEPGS-03659 Excinuclease ATPase subunit TCATTCAAGATGATTCATT 8.8 N <0.001
VEPGS-03814 NADPH:quinone reductase and related Zn-dependent oxidoreductases TCGGAGAACCTTATGTTTA 8.45 N <0.001
VEPGS-03822 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase AAAGGGAAGCTTATGCTTC 8 N <0.001
VEPGS-03826 Type IIA topoisomerase (DNA gyrase/topoisomerase II, topoisomerase IV), B subunit TCTTCACGCTCAGAGTTAA 8.1 N <0.001
VEPGS-03844 FoF1-type ATP synthase, subunit b TGATTAACCTAGTTGACCA 7.75 N <0.001
VEPGS-03847 FoF1-type ATP synthase, gamma subunit TATTCAACAAGTTTGTAAA 8.3 N <0.001
VEPGS-03856 Dihydroxyacid dehydratase/phosphogluconate dehydratase TGATTCGTCATCTTGCTCG 8.15 N <0.001
VEPGS-03880 Zn finger domain associated with topoisomerase type I ATGTGACCATCATTGCTGT 8.1 N <0.001
VEPGS-03964 Aspartate ammonia-lyase TGGTCTCCTTCTTTTTTAG 13.6 N <0.001
VEPGS-04037 Exoribonuclease R TCGTTTGACGACATGGATT 8.65 Y <0.001
VEPGS-04051 Iron-sulfur cluster-binding protein CTTTCAATCTCTTGCATAT 8.85 N <0.001
VEPGS-04106 Predicted transcriptional regulators (AphA) TATTCCACTTCATGCTTAT 14.62 Y <0.001
VEPGS-04284 Small RNA, CsrB family CATTGAATTTAATACTCAT 8.75 N <0.001
VEPGS-04291 Putative multidrug resistance protein TCATTCCGGCTTTAGCTCC 7.7 N <0.001
VEPGS-04316 Regulator of sigma D (anti-σD) TTATCGTTAAGTAAATGTG 7.9 N <0.001
VEPGS-04317 DNA-directed RNA polymerase beta′ subunit TATAGATCGTTAAGATCAG 7.55 Y <0.001
VEPGS-04318 DNA-directed RNA polymerase beta subunit ACAGGCGAGATCATTGTTA 7.55 N <0.001
VEPGS-04329 Vitamin B12 receptor TATTCGCACTCTTGTCTTT 7.95 N <0.001
VEPGS-04332 Transcriptional regulator (FabR) TATGTCTATAAATTGCATC 12.6 N <0.001
VEPGS-04337 Glycerol-3-phosphate acyltransferase TAATTGCCCAAATGCTCAT 8.1 N <0.001
VEPGS-04385 Adenylate cyclase TATGGTTTTGTATCCAGAT 7.7 N <0.001
VEPGS-04400 Predicted transcriptional regulators TTTTACCCTCTAATCTTCT 8.35 N <0.001
VEPGS-04448 d-Erythrose 4-phosphate dehydrogenase TATGCAACTTAGTGTCCAC 11.45 N <0.001
VEPGS-04453 UDP-N-acetylmuramate dehydrogenase ACCGATCCCCTGATTCACA 9.75 N <0.001
VEPGS-04457 Putative translation factor AACGCGGCATCAAAGTTAT 7.9 N <0.001
VEPGS-04459 Shikimate 5-dehydrogenase TGCACCTGTTGATGGTTTT 8.85 N <0.001
VEPGS-01281 Transcriptional regulators of sugar metabolism TATAAAGCGTTTTGCCTTT 8.8 N <0.001
VEPGS-01343 5′-Nucleotidase/2′,3′-cyclic phosphodiesterase and related esterases TCTGCGCCTTCTTTCTTCA 9.65 N <0.001
VEPGS-01349 Hypothetical protein AAAGTGGCCTGATGGACAT 8.1 N <0.001
VEPGS-01356 50S ribosomal protein L15p TAGTTGCCATGGTGTTCTT 7.6 N <0.001
VEPGS-01395 UDP-glucose 6-dehydrogenase TGATAAGCTTTCTGCTTAT 8.45 N <0.001
VEPGS-01401 Hypothetical protein CGTATCACCTGTTACTGAT 7.95 N <0.001
VEPGS-01451 ABC-type oligopeptide transport system, periplasmic component AAAGCCAAATCGTGCTTTT 8.4 N <0.001
VEPGS-01456 Biopolymer transport proteins TAGTTCAGTCAGCTGCTTA 7.85 N <0.001
VEPGS-01492 Disulfide bond chaperones of the HSP33family TGCTTTGCCTTCATGCTCA 7.75 N <0.001
VEPGS-01503 Signal transduction histidine kinase, nitrogen specific TGAACAATCACTTTCTCAA 8.75 N <0.001
VEPGS-01511 Cytochrome c553 TATAAAGCGTTTTGCCTTT 7.9 N <0.001
VEPGS-01513 5′-3′ exonuclease (including N-terminal domain of polymerase I) TAAGCTGATTTTTGCCTTT 7.65 Y <0.001
VEPGS-01530 Hypothetical protein ATATGCCACTCCTTATTTA 7.65 N <0.001
VEPGS-01564 Hypothetical protein ACTGGCAACCTGATTGTTC 8.6 N <0.001
VEPGS-01566 Peptide ABC transporter, permease protein TCTATCGACATCATGGATT 8 N <0.001
VEPGS-01569 Peptide ABC transporter, ATP-binding protein CATTAACCATATTATTCAT 8.95 N <0.001
VEPGS-01574 Transcriptional regulator TTGGTATCTTGATACTCGT 8.7 N <0.001
VEPGS-01579 Transcriptional regulator TCTTTGGCTTTATTTTCAT 8.75 N <0.001
VEPGS-01835 OpaR (LuxR) TAGTGTATCACCACGTTCA 4.11 N <0.001
VEPGS-02615 RNA polymerase sigma factor TATTCGCACTCTTGTCTTT 7.75 N <0.001
VEPGS-02635 Glutamine synthetase adenylyltransferase CCTTCACGATCTTTCACAT 8.2 N <0.001
VEPGS-02651 Cytochrome b subunit of the bc complex TACTCTACATCACGCATAA 7.95 N <0.001
VEPGS-02767 Hypothetical protein TTATTAAACTATATTCATA 15.5 N <0.001
a

The genes discussed in the text are in bold. ID, identifier.

b

The corresponding gene in ChIP-seq hits was also regulated (Y) or not regulated (N) in V. harveyi as revealed by microarray assays (4, 14).