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. 2016 Oct 7;198(21):3016–3028. doi: 10.1128/JB.00530-16

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Copyright © 2016 Szafran et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 5 — Changes in chromosomal supercoiling and topA and gyrB gene transcription after novobiocin treatment. (A) Analysis of the supercoiling density (σ) of the reporter pWHM3Hyg plasmid isolated from the wild-type strain cultured for up to 120 min in the presence of novobiocin (5 μg/ml). (B) Relative transcription levels of p2-specific (p2) and overall (p1 + p2) topA transcripts in the wild-type strain in the presence of novobiocin (up to 5.0 μg/ml). (C) RT-qPCR analysis of gyrB transcript levels in the wild-type strain in the presence of increasing concentrations of novobiocin (up to 5.0 μg/ml).