Table 1.

Gaps in Knowledge and Recommendations for Future Interventions Targeting CNS-mediated Mobility Impairment: Summary of Workshop Round Table Discussions

	Recommendations
Recruitment and sample selection	Develop consensus inclusion and exclusion criteria for the novel phenotype
	Determine the gait measures required to define criteria
	Identify community-based and clinical recruitment centers (eg, ADRCs)
	Recruit from diverse and understudied populations
Intervention design	Consider adaptive and individually tailored interventions
	Focus on multimodal interventions that can target multiple pathways simultaneously
	Strive for enjoyable and challenging interventions to increase adherence and maintenance
	Consider variable impact by subgroups (eg, sex, age, disability)
	Carefully select control participants
	Include cross-disciplinary teams in intervention development
Methods to measure effectiveness	Focus on multiple and dependent pathways
	Incorporate qualitative and quantitative markers of brain health
	Develop a detailed baseline phenotype of study participants including multiple cognitive and mobility measures
	Consider noninvasive, wearable technology to assess outcomes continuously in daily life

Note: ADRC = Alzheimer’s Disease Research Center; CNS = central nervous system.