Table 1.

Baseline characteristics of participants

	Normal diastolic function (E/e’mean < 8) n = 30	With evidence of diastolic LV dysfunction (E/e’mean ≥ 8 & LAVmax ≥ 34 mL/m2) n = 26	p-value
Anthropometry
Women [%]	4 (13 %)	10 (38 %)	0.07
Age [yrs]	52.3 ± 15.1	64.8 ± 9.3	0.001
Weight [kg]	76.5 ± 9.7	78.3 ± 12.8	0.63
Height [m]	1.76 ± 0.07	1.71 ± 0.08	0.02
Body mass index [kg/m2]	24.7 ± 2.6	26.7 ± 3.7	0.01
Fat Free Mass [kg]	63.0 ± 9.5	57.2 ± 6.8	0.09
Body surface area [m2]	1.92 ± 0.14	1.90 ± 0.18	0.55
Cardiovascular Risk Factors
Hypercholesterolemia (total cholesterol ≥6.21 mmol/L)	5 (17 %)	7 (27 %)	0.61
RRsys/RRdia	128 ± 16/83 ± 10	144 ± 22/85 ± 9	0.01/0.25
Hypertension (RRsys > 140 mmHg or RRdia > 90 mmHg)	9 (30 %)	16 (62 %)	0.07
Echocardiography
Heart rate [bpm]	59 ± 11	68 ± 10	0.001
3D-EFLV [%]	59.7 ± 5.2	60.6 ± 12.0	0.14
LV mass [g/m2]	86.6 ± 16.0	96.9 ± 30.4	0.35
E [cm/s]	68.4 ± 18.1	79.6 ± 16.4	0.02
Left ventricle internal diameter, diastole [mm]	47 ± 6	39 ± 11	0.002
Posterior wall thickness, diastole [mm]	11 ± 2	13 ± 3	<0.001
Septum wall thickness, diastole [mm]	11 ± 2	14 ± 3	<0.001
A [cm/s]	60.6 ± 14.5	79.2 ± 20.0	0.001
E/A ratio	1.20 ± 0.44	1.05 ± 0.35	0.10
Dct [ms]	218 ± 8	262 ± 6	0.004
e’lat [cm/s]	14.0 ± 3.6	8.9 ± 2.7	<0.001
E/e’lat	5.01 ± 1.12	9.9 ± 4.6	<0.001
e’med [cm/s]	9.3 ± 2.8	6.4 ± 1.5	0.001
E/e’med	7.42 ± 1.57	13.01 ± 3.46	<0.001
E/e’ mean	5.55 ± 1.33	11.30 ± 2.92	<0.001
E/e’ mean [range]	2.9–7.9	8.0–20.0	<0.001

Mean ± SD or median (IQR)

(RR _sys /RR _dia systolic and diastolic blood pressure, E early diastolic filling peak velocity, A peak velocity during atrial contraction, Dct Deceleration time of the E-wave velocity, e’ _lat early diastolic mitral annular velocity free LV wall, e’ _med early diastolic mitral annular velocity septal)