Table 4.
Allele and genotypes frequencies distribution of ELMO1 variants in DN and HC subjects
| SNP ID | Allele/Genotype | DN (n = 100) N (%) |
HC (n = 100) N (%) |
p value | OR (95 % CI) |
|---|---|---|---|---|---|
| 1345365 | A | 143 (71.5) | 138 (69) | 0.2 | 1.1 (0.7–1.7) |
| G | 57 (28.5) | 62 (31) | 0.2 | 0.8 (0.5–1.3) | |
| AA | 51 (51) | 47 (47) | 0.3 | 1.1 (0.6–2) | |
| AG | 41 (41) | 44 (44) | 0.1 | 0.8 (0.5–1.5) | |
| GG | 8 (8) | 9 (9) | 0.7 | 0.8 (0.3–2.3) | |
| HWE | 0.9 | 0.7 | |||
| rs741301 | A | 106 (53) | 129 (64.5) | 0.01 | 0.6 (0.4–0.9) |
| G | 94 (47) | 71 (35.5) | 0.01 | 1.6 (1.1–2.5) | |
| AA | 32 (32) | 44 (44) | 0.08 | 0.5 (0.3–1) | |
| AG | 42 (42) | 41 (41) | 0.8 | 1 (0.5–1.8) | |
| GG | 26 (26) | 15 (15) | 0.05 | 2 (1–4.1) | |
| HWE | 0.1 | 0.2 |
HWE Hardy-Weinberg equilibrium, DN Type 2 diabetes with Nephropathy, HC Healthy Control