Table 3.
Risks of the primary outcome in intensive vs. standard blood pressure-lowering treatment arms stratified by sex, race, and glycemia trial assignment in the Action to Control Cardiovascular Risk in Diabetes blood pressure trial
| Stratifying variable | Standard blood pressure- lowering arm | Intensive blood pressure- lowering arm | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|---|---|
| Events (n)/event rate per 1,000 person-years | Events (n)/event rate per 1,000 person-years | Hazard ratio (95% CI) | P | Hazard ratio (95% CI) | P | Hazard ratio (95% CI) | P | |
| Sex | ||||||||
| Men | 302/87.7 | 270/77.4 | 0.88 (0.74−1.03) | 0.11 | 0.87 (0.74−1.03) | 0.11 | 0.86 (0.73−1.01) | 0.07 |
| Women | 260/81.1 | 231/70.1 | 0.88 (0.74−1.05) | 0.15 | 0.88 (0.74−1.05) | 0.15 | 0.88 (0.73−1.05) | 0.14 |
| Race | ||||||||
| White | 320/79.7 | 300/71.7 | 0.90 (0.77−1.06) | 0.21 | 0.91 (0.77−1.06) | 0.21 | 0.90 (0.77−1.06) | 0.20 |
| Non-White | 242/92.0 | 201/77.4 | 0.85 (0.70−1.02) | 0.08 | 0.85 (0.70−1.02) | 0.08 | 0.84 (0.69−1.01) | 0.06 |
| Glycemia trial assignment | ||||||||
| Standard glycemia control | 277/86.2 | 258/74.9 | 0.88 (0.74−1.04) | 0.13 | 0.87* (0.74−1.04) | 0.12* | NA | NA |
| Intensive glycemia control | 285/83.0 | 243/72.8 | 0.88 (0.74−1.04) | 0.14 | 0.86* (0.73−1.03) | 0.10* | NA | NA |
Model 1: unadjusted. Model 2: adjusted for glycemia trial assignment. Model 2 for glycemia trial assignment subgroups is adjusted for baseline CVD*. Model 3: adjusted for glycemia trial assignment and baseline CVD.
Abbreviations: CI, confidence interval; CVD, cardiovascular disease; NA, not applicable.