Table 2.
Regional BPND in underweight patients with Anorexia Nervosa (AN) vs. Control Subjects (CTR)a
| Region | AN, underweight (SE) n=21 [95% CI] |
CTR (SE) n=25 [95% CI] |
Statistic (underweight AN vs CTR) |
Cohen’s d |
|---|---|---|---|---|
| Striatum, whole | 2.60 (0.077) [2.15–3.05] |
2.55 (0.076) [2.04–3.06] |
[F(1,42.47)=0.45; p=0.50] | 0.14 |
| Sensorimotor striatum | 3.06 (0.122) [2.17–3.94] |
3.05 (0.121) [2.08–4.02] |
[F(1,42.32)=0.003; p=0.95] | 0.02 |
| Associative striatum | 2.53 (0.060) [2.29–2.77] |
2.47 (0.057) [2.18–2.76] |
[F(1,42.79)=0.80; p=0.38] | 0.22 |
| Limbic striatum | 2.21 (0.055) [2.00–2.42] |
2.14 (0.052) [1.89–2.40] |
[F(1,42.81)=1.18; p=0.28] | 0.27 |
Regional BPND (unitless measure) with standard error are presented, for 21 underweight patients with AN, compared to 25 healthy control subjects without history of an eating disorder. For the primary analysis (differences in D2 BPND in the striatum as a whole, between underweight patients with AN and control subjects), outcome measure estimates and statistics were derived from a mixed models analysis incorporating all 3 regions, with fitted parameters of intercept, diagnosis, and age. For derivation of the subregion outcome measures, parallel F and p statistics, and 95% confidence intervals (CI’s), a similar mixed models analysis was completed for each individual region. (Estimates of the subregion BPNDs were also generated from the full mixed model analysis, and were very similar [not shown here].)