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. Author manuscript; available in PMC: 2017 Oct 8.
Published in final edited form as: Bioorg Med Chem. 2016 Apr 8;24(11):2530–2543. doi: 10.1016/j.bmc.2016.04.019

Scheme 4.

Scheme 4

Reagents and conditions: i) Et3N, anhydrous THF, ethyl chloroformate, 4-bromoaniline, −5 °C and then rt, 17.5 h; ii) DMF/DMA, 90°C, 3 h; iii) Mo(CO)6, H2O, CH3CN, reflux, 2h; iv) N2H4. H2O, EtOH, reflux, 3 h; v) CH3I, K2CO3, anhydrous DMF, 90°C, 3 h; vi) 3- or 4-methozybenzenboronic acid, (CH3COO)2Cu, Et3N, anhydrous CH2Cl2, rt, 16 h.