. Author manuscript; available in PMC: 2017 Oct 8.

Published in final edited form as: Bioorg Med Chem. 2016 Apr 8;24(11):2530–2543. doi: 10.1016/j.bmc.2016.04.019

Table 3.

Chemoattractant activity of selected pyridazinones in human neutrophils

Compd	EC₅₀ (µM)^[a] in migration assay
8a	2.2 ± 0.51
15	1.2 ± 0.24
27a	1.1 ± 0.22
27b	0.45 ± 0.17

^[a]

The data are presented as the mean ± SD of three independent experiments with cells from different donors, in which median effective concentration values (EC₅₀) were determined by nonlinear regression analysis of the concentration-response curves (5–6 points) generated using GraphPad Prism 5 with 95% confidential interval (p < 0.05).