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. Author manuscript; available in PMC: 2016 Dec 27.
Published in final edited form as: Biometrics. 2016 Apr 8;72(4):1066–1077. doi: 10.1111/biom.12519

Table 4.

Sample size effect and correlation magnitude effects for data generation mechanism given in Equation 5 with βO = (1,1,1, 1,1) and βM = (−3, 1/2, 1/2, 1/2, 1/2). Statistics for 1000 replicates are the bias compared to ME, the empirical standard errors over the replicates, the mean asymptotic nuisance-adjusted standard errors and the coverage for the GEE, the IPW, the AUG and the DR with independence (−I) and exchangeable (−E) working correlation matrix.

ME
Bias Standard Error (SE) Coverage
Empirical Robust Fay’s Robust Fay’s
−I −E −I −E −I −E −I −E −I −E −I −E
Small sample M = 10, ni = (10, 20, 30) with probability 1/3 each, Low correlation
GEE 2.0 −1.7473 −1.7479 0.4351 0.4360 0.3963 0.3256 0.4559 0.4603 0.8 2.3 3.9 4.9
IPW 2.0 −1.0130 −1.0130 0.6793 0.6842 0.5538 0.5591 0.6735 0.6766 49.0 49.2 59.8 59.9
AUG 2.0 −1.8099 −1.8111 0.3371 0.3269 0.8362 0.8353 0.8834 0.8817 29.7 29.1 40.1 39.2
DR 2.0 0.0008 0.0006 0.1552 0.1586 0.1127 0.1140 0.1190 0.1201 84.8 83.8 86.0 86.2

Large sample M = 100, ni = (90,100,110) with probability 1/3 each, Low correlation
GEE 2.0 −1.7335 −1.7321 0.1015 0.1013 0.0985 0.0727 0.0994 0.0994 0.0 0.0 0.0 0.0
IPW 2.0 −0.9955 −0.9952 0.1514 0.1517 0.1559 0.1563 0.1588 0.1592 0.2 0.2 0.2 0.2
AUG 2.0 −1.8019 −1.8022 0.0695 0.0664 0.2556 0.2550 0.2569 0.2563 0.0 0.0 0.0 0.0
DR 2.0 0.0016 0.0017 0.0265 0.0265 0.0262 0.0263 0.0264 0.0264 95.1 95.0 95.1 95.2

Small sample M = 10, ni = (10, 20, 30) with probability 1/3 each, High correlation
GEE 2.0 −0.0086 −0.0086 0.5265 0.5314 0.4701 0.4721 0.5651 0.5657 88.5 88.4 92.9 92.7
IPW 2.0 −1.0221 −1.0229 0.7026 0.7083 0.5776 0.5829 0.7015 0.7044 52.4 52.2 62.2 61.5
AUG 2.0 −1.7985 −1.7987 0.5058 0.5084 0.8748 0.8727 0.9243 0.9209 35.8 35.8 45.1 45.5
DR 2.0 0.0098 0.0062 0.4328 0.4407 0.2469 0.2480 0.2607 0.2614 77.4 77.7 79.7 79.6

Large sample M = 100, ni = (90, 100, 110) with probability 1/3 each, High correlation
GEE 2.0 −1.7325 −1.7312 0.1145 0.1141 0.1121 0.0753 0.1132 0.1132 0.0 0.0 0.0 0.0
IPW 2.0 −0.9945 −0.9940 0.1618 0.1620 0.1652 0.1656 0.1682 0.1686 0.2 0.2 0.2 0.2
AUG 2.0 −1.8014 −1.8017 0.0787 0.0761 0.2587 0.2581 0.2600 0.2594 0.0 0.0 0.0 0.0
DR 2.0 0.0029 0.0032 0.0609 0.0610 0.0590 0.0590 0.0593 0.0593 94.7 94.6 94.7 94.6
Marginal model for the GEE:
μij(β,Ai)=β0+βAAi
OM in AUG and DR is fitted for each treatment group Ai = a using a stepwise regression:
Bij(Xi,Ai=a)=stepwise(Xij1,Xij2,Xij3,X1¯i.,X2¯i.,X3¯i.)
PS in DR and IPW is fitted for the whole dataset using a stepwise regression:
logit(πij(Xi,Ai))=stepwise(Ai,Xij1,Xij2,Xij3,X1¯i.,X2¯i.,X3¯i.)