Table 6.
Study definitions of good response according to histopathological tumour regression grade scales
| Ref. | Year | TRG scale used (original disease application) | Are the scales reported accurately? | Good response definition | Total (n) | Good responders (n) | Average F/up in months | LR (%) 5 yr | DR (%) 5 yr | DFS (%) | OS (%) |
| Gambacorta et al[21] | 2004 | Mandard (oesophagus) | Yes | TRG 1 and 2 | 54 | 24 | 25 | ||||
| Pucciarelli et al[28] | 2004 | Mandard (oesophagus) | Yes | TRG 1 and 2 and 3 | 104 | 52 | 42 | DNE | DNE | ||
| Horisberger et al[24] | 2008 | Japanese Society for Cancer of the Colon and Rectum (rectal) | Yes | TRG 2 and 3 | 59 | 33 | |||||
| Suárez et al[31] | 2008 | Mandard (oesophagus) | Yes | TRG 1 and 2 | 119 | 36 | 33 | 0 | 0 | DNE | |
| Bujko et al[18] | 2010 | Glynne Jones/Bujko (rectal) | Yes | TRG 1 | 131 | 40 | 48 | 9 | 34 | Yr. 4: 67 | |
| Avallone et al[13] | 2011 | Mandard (oesophagus) | Yes | TRG 2 and 3 | 63 | 20 | 60 | Yr. 5: Prob free of recurrence > 90% | |||
| Shin et al[30] | 2011 | Mandard (oesophagus) | Yes | TRG 1 and 2 and 3 | 102 | 52 | 40.3 | Yr. 3: 74.1 | |||
| Huebner et al[25] | 2012 | Dworak (rectal) | Yes | TRG 2 and 3 and 4 | 237 | 176 | |||||
| Lim et al[26] | 2012 | Dworak (rectal) | Yes | TRG 3 and 4 | 581 | 224 | 61 | 1.3 | 11.6 | Yr. 5: 86.7 | Yr. 5: 88.2 |
| Roy et al[29] | 2012 | Dworak (rectal) | Yes | TRG 2 and 3 and 4 | 75 | 33 | Yr. 2: 91.7 | Yr. 2: 89.2 | |||
| Roy et al[29] | 2012 | Mandard (oesophagus) | Yes | TRG 1 and 2 and 3 | 75 | 51 | Yr. 2: 86.1 | Yr. 2: 92.2 | |||
| Vallböhmer et al[32] | 2012 | Japanese Society for Cancer of the Colon and Rectum (rectal) | Yes | TRG 3 | 85 | 23 | DNE | ||||
| Vallböhmer et al[32] | 2012 | Junker Miller (lung) | Yes | TRG 2aand2b | 85 | 65 | DNE | ||||
| Vallböhmer et al[32] | 2012 | Cologne (oesophageal) | Yes | TRG 3 and 4 | 85 | 26 | DNE | ||||
| Winkler et al[33] | 2012 | Dworak (rectal) | No | TRG 3 | 33 | 6 | |||||
| Elezkurtaj et al[20] | 2013 | Dworak (rectal) | Yes | TRG 3 and 4 | 102 | 34 | |||||
| Fokas et al[14] | 2014 | Dworak (rectal) | Yes | TRG 2 and 3 | 386 | 256 | 132 | Yr. 10: 8.0 | Yr. 10: 29.3 | Yr. 10: 73.6% | |
| Santos et al[16] | 2014 | Dworak (rectal) | Yes | TRG 3 and 4 | 144 | 54 | 56 | 1.8 | 11.1 | Yr. 5: 78.4 | Yr. 5: 77.4 |
| Santos et al[16] | 2014 | Mandard (oesophagus) | Yes | TRG 1 and 2 | 144 | 70 | 56 | 1.4 | 8.6 | Yr. 5: 81.7 | Yr. 5: 79.4 |
| Hav et al[15] | 2015 | Dworak (rectal) | Yes | TRG 3 and 4 | 76 | 28 | 20 | No specific data but no correlation with DFS |
Overall rate for total follow-up time. LR: Local recurrence; DR: Distant recurrence; DNE: Data given but not extractable; DFS: Disease-free survival.