Fig. 4.

Changes in risk group classification according to dosing interval. R _d: dissolution rate, R _a: absorption rate relative to total absorption until the indicated time point. a 1 min (actually simultaneous). b 30 min. c 60 min. d 120 min. R _d and R _a were plotted. The number (n) of drugs classified into each group when threshold values of R _d and R _a were set as 90 and 30 %, respectively, is shown. 1, amlodipine; 2, aspirin, dihydroxyaluminum aminoacetate, magnesium carbonate (Bufferin combination tablet); 3, losartan; 4, metoprolol ER; 5, nifedipine; 6, triazolam; 7, allopurinol; 8, ambroxol; 9, ambroxol ER; a, arotinolol; b, aspirin (Bayaspirin); c, atenolol; d, atorvastatin; e, azosemide; f, bacampicillin; g, benidipine; h, betaxolol; i, brotizolam; j, cefcapene pivoxil; k, cefdinir; l, celiprolol; m, cetirizine; n, clarithromycin; o, clonidine; p, clotiazepam; q, cyclosporine; r, digoxin; s, dilazep; t, enalapril; u, epalrestat; v, epinastine; w, etizolam; x, etodolac; y, famotidine; z, furosemide; A, glibenclamide; B, guanabenz; C, ibuprofen; D, imidapril; E, indapamide; F, isosorbide; G, lansoprazole; H, levofloxacin; I, lisinopril; J, loxoprofen; K, metformin; L, metoprolol; M, naftopidil; N, nateglinide; O, nicorandil; P, nilvadipine; Q, omeprazole; R, perindopril; S, pioglitazone; T, pravastatin; U, propranolol ER; V, rabeprazole; W, rebamipide; X, sodium ferrous citrate; Y, tamsulosin ER; Z, temocapril; δ, ticlopidine; ζ, tizanidine; θ, torasemide; λ, trandolapril; π, trichlormethiazide; σ, warfarin; ϕ, zolpidem