Table 2.
Effect of TNF-α mAb on pro- and anti-inflammatory cytokine mRNA expression in LPS-stimulated monocytes.
| Area under the curve (AUC) ΔCT. hours(median,range) | ||||||
|---|---|---|---|---|---|---|
| TNF-α | CXCL8 | IL-1β | IL-6 | IL-10 | TGF-β | |
| LPS | 159 (86–233) | 3050 (2170–3697) | 1571 (1436–1891) | 242 (120–1022) | 11 (8–13) | 33 (21–50) |
| LPS and TNF-α mAb | 152 (54–197) | 2248 (1679–2988) | 940 (885–1394) | 144 (93–235) | 6 (4–10) | 29 (18–49) |
| p value | 0.03 | 0.03 | 0.03 | 0.03 | ||
The table outlines area under the curve values for time course profiles of each of the cytokines in response to LPS or LPS stimulation in the presence of TNF-α mAb (n = 4). AUC values were compared with a Wilcoxon Signed-Rank Test. p values are one-tailed.