Fig. 1.

Analysis of substrate induced structural rearrangements of furin. (A) Overall structure of human unliganded furin (catalytic and the P-domains are in gold and blue, respectively). The catalytic residues (cyan stick model), the substrate binding pockets (labeled S1–S5), and bound ions (purple sphere, Na⁺; green spheres, Ca²⁺) are indicated. (B) The Cα-displacement values (intervals <0.3 Å, 0.3–0.8 Å, and >0.8 Å are highlighted in cyan, yellow, and magenta, respectively) were mapped to the molecular surface.