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. 2016 Sep 19;113(40):11318–11323. doi: 10.1073/pnas.1613337113

Fig. 1.

Fig. 1.

Projections from striosomes, but not from matrix, target dopamine-containing dendrons in the SN. (A, D, and G) Confocal images of striatum with striosome-predominant fluorophore labeling (A; n = 30 sections from 5 animals), P172-mCitrine labeling (D; n = 24 sections from 4 animals), and matrix-predominant labeling (G; n = 30 sections from 10 animals) in the CalDAG-GEFI-GFP line. (B, E, and H) The same sections with μ-opioid receptor coimmunolabeling of striosomes for all lines (n = 4–8 sections from 2 animals). (C, F, and I) Corresponding merged images. (Insets) Examples of striosomes (asterisks). (J, M, and P) Fluorophore labeling of dendrons in the SN of CalDAG-GEFII (J; n = 10 sections from 5 animals) and P172 (M; n = 16 sections from 4 animals) striosome lines and a near-lack of dendron labeling in the CalDAG-GEFI matrix line (P; n = 6 sections from 2 animals). (K, N, and Q) the same sections with DAT immunolabeling of dendrons. (L, O, and R) Merged images.