Table 1.
Roles of cytokines in epithelial function
| Epithelial function | Regulatory cytokines | Target cells |
|---|---|---|
| Barrier | IFNγ, TNFα, IL-1β, IL-10, IL-6, IL-22, IL-4, IL-13 | IECs |
| Leukocyte recruitment | IL-8, MCP-1, CCL20 | Leukocytes |
| Antigen presentation | IFNγ, TSLP, APRIL | IECs, dendritic cells, B cells |
| Homeostasis | IL-10, TGFβ, TSLP, APRIL, IL-25, IL-22 | IECs, dendritic cells, macrophages, B cells |
| Proinflammatory response(s) | IFNγ, TNFα, IL-1β, IL-8 | IECs, leukocytes |
| Regulation of solute/water transport | IFNγ, IL-4, IL-13 | IECs |