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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Epilepsia. 2016 Aug 24;57(10):1546–1557. doi: 10.1111/epi.13510

Figure 3. Relationship between cross-hippocampal connectivity and Granger causality laterality with duration of illness in MTLE.

Figure 3

A) Location of the left hippocampus (red) and right hippocampus (green) functional ROIs determined using 2dTCA. B) Relationship between hippocampal connectivity and duration of disease across patients with left and right MTLE using functional ROIs, showing a linear increase in hippocampal connectivity with increasing duration of disease after 10 years. C) Granger causality laterality versus duration of disease. Positive laterality indicates left hippocampus influences right. Negative laterality indicates right hippocampus influences left. 2dTCA: modified temporal clustering algorithm; MTLE: mesial temporal lobe epilepsy; ROI: region of interest. Modified with permission from Morgan et al., 2011.28