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. 2016 Oct 10;7:1614. doi: 10.3389/fmicb.2016.01614

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Copyright © 2016 Wang, Huang, Ding, Chen, Fang, Huang and Fang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme of the yqiC regulatory network in Salmonella. This scheme summarizes the role of yqiC in the regulation of type-1 fimbrial, SPI-1, SPI-2, and flagellar genes. YqiC enhances menaquinone biosynthesis and its related electron transport chain, negatively controls FimZ and its downstream regulatory network, and positively manipulates FliZ and its subsequent flagellation. Our data supported that YqiC can suppress the expression of type-1 fimbriae in Salmonella. The activation of the type-1 fimbrial regulator FimZ can inhibit the expression of flagellar, SPI-1, and SPI-2 genes by inhibiting the regulators HilD, HilA, SsrA/B, and FliZ, resulting in the suppression of the host immune responses, including the expression of IL-8 and hBD-3. The solid and dotted lines indicate well-documented regulations and putative connections in the regulator network, respectively.