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Purinergic 2X7 receptor inhibition reduces the phosphorylation of p65 in PMA-induced macrophages. THP-1 cells silenced for P2X7R were used to obtain a whole-cell extract as described under Materials and Methods. (A) Representative Western blot analysis of TLR4, MyD88, p-P65, and P65 was normalized based on the internal control GAPDH. (B,C) Densitometry measurements of protein analysis. The results represent the mean ± SEM for three experiments. ∗P < 0.05 vs. PMA group.
