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Schematic model for the reduction of NLRP3 inflammasome expression in PMA-stimulated macrophages treated with curcumin. The curcumin-downregulated P2X7R expression and TLR4/MyD88/NF-κB signaling, which together inhibited NLRP3 expression, caspase-1 activation, and the secretion of IL-1β.
