Skip to main content
. 2016 Oct 5;173(21):3080–3087. doi: 10.1111/bph.13550

Figure 1.

Figure 1

SYKi attenuates FcεR cross‐linking‐induced airway constriction but does not attenuate carbachol‐induced contraction in hPCLS. (A) Representative time course of airway constriction to FcεR cross‐linking assessed in the absence/presence of SYKi (0.1, 0.3, 1 μM) over a course of 10 min. Constriction was measured compared with baseline luminal area and expressed as % airway constriction. (B) Representative plot of inhibition measured out to 30 min following cross‐linking. (C) Maximal constriction following FcεR cross‐linking was compared. (D) Following cross‐linking, hPCLS were stimulated with carbachol (Cch; 100 μM) and % airway constriction measured. Data shown are means ± SEM and are from nine individual donors. * P ≤ 0.05, significantly different as indicated.