Figure 4.

Effects of GS‐6615 to shorten the prolonged MAP and to suppress ventricular tachyarrhythmia induced by ATX‐II in rabbit isolated heart preparations. Shown in panels A–D are representative sequential recordings of epicardial MAP (top record in each panel) and pseudo‐ECG (bottom record in each panel) during exposure of a heart to perfusate alone (control, A), ATX‐II alone (B) and GS‐6615 (0.1 and 0.3 μM) in the continued presence of ATX‐II (C and D). Shown in panels E and F are concentration–response relationships for GS‐6615 to shorten the MAPD₉₀ and to reduce the incidence of VT during exposure of hearts to ATX‐II. Data shown are means±SEM ; n=5. *P<0.05; repeated measures one‐way ANOVA, with Student–Newman–Keul's test.