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Inhibition by GS‐6615 or flecainide of peak INa in rabbit ventricular myocytes
| Holding Potential | GS‐6615 (10 μM) | Flecainide (10 μM) | ||
|---|---|---|---|---|
| Stimulating frequency | Stimulating frequency | |||
| 0.1 Hz | 3 Hz | 0.1 Hz | 3 Hz | |
| −120 mV | 8.8 ± 2.1% (n = 5) | 16.6 ± 3.2% (n = 5) | 7.0 ± 2.9% (n = 6) | 40 ± 2.6% (n = 6) |
| −90 mV | 12.0 ± 1.5% (n = 5) | 19.5 ± 1.7% (n = 8) | 21.6 ± 1.0% (n = 5) | 65.3 ± 2.4% (n = 4) |
