Figure 1.

Direct activation of glycine and GABA_A receptors. (A) Sample currents from oocytes expressing α1, α2 or α3 glycine (GlyR) or α1β3γ2L GABA_A receptors (GABA_AR). The receptors were activated by 100 μM 4‐bp, 4‐CP or 4‐FP (left trace in each pair) or a saturating concentration of glycine (1 mM, 0.5 mM or 2 mM for α1, α2 and α3 respectively) or GABA (1 mM). In each pair, the traces for propofol analogue and glycine (or GABA) are from the same cell. (B) Summary of direct activation of glycine and GABA_A receptors by saturating concentrations of propofol and its analogues. The responses (mean ± SEM) are normalized to responses to saturating concentrations of the transmitter from the same sets of cells.