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Effects of PGE2 and other EP receptor agonists on Spn‐induced TNF‐α generation. Macrophages were pre‐incubated (30 min) with indomethacin (1 μM) and then with or without either PGE2, L‐902,688 or butaprost for 30 min before challenge with Spn (MOI of 1) for 22 h after which TNF‐α was measured in the supernatants. Results are expressed as the % inhibition of the control cytokine release, which was 1346 ± 669 pg·mL−1 of TNF‐α. Data shown are means ± SEM for four experiments.
