Figure 2.

Anatomy of the diseased aorta adventitia in aged hyperlipidemic mice. Aged hyperlipidemic mice develop ATLOs in the adventitia layer of the aorta selectively adjacent to atherosclerotic plaques with a preference for the abdominal aorta segment. ATLOs range from small T/B-cell aggregates to well-structured TLOs with separate T- and B-cell areas. The most advanced forms of ATLOs contain B-cell follicles including FDCs, newly formed conduits, HEVs, and aberrant lymph vessels (see Figure 4).