Table 2. Association between HLA DQB1 and DRB1 alleles with GDM.
| HLA | Number of populations | OR (95%CI) | P | Adjusted P | Ph | I2 |
|---|---|---|---|---|---|---|
| DQB1*02 | 6 | 1.36 (1.13–1.63) | 0.001 | 0.034 | 0.538 | 0 |
| DQB1*0201 | 6 | 1.48 (0.89–2.47) | 0.129 | 1 | 0.044 | 56.23 |
| DQB1*0203 | 2 | 3.27 (1.21–8.81) | 0.019 | 0.646 | 0.601 | 0 |
| DQB1*0301 | 4 | 0.90 (0.55–1.47) | 0.673 | 1 | 0.017 | 70.40 |
| DQB1*0302 | 9 | 1.03 (0.88–1.20) | 0.755 | 1 | 0.780 | 0 |
| DQB1*0303 | 3 | 1.05 (0.57–1.95) | 0.866 | 1 | 0.792 | 0 |
| DQB1*0305 | 3 | 0.93 (0.41–2.12) | 0.857 | 1 | 0.611 | 0 |
| DQB1*0401 | 2 | 0.82 (0.31–2.18) | 0.694 | 1 | 0.984 | 0 |
| DQB1*0402 | 4 | 0.35 (0.16–0.78) | 0.010 | 0.340 | 0.718 | 0 |
| DQB1*0501 | 3 | 1.03 (0.63–1.71) | 0.899 | 1 | 0.948 | 0 |
| DQB1*0502 | 4 | 1.12 (0.57–2.19) | 0.744 | 1 | 0.597 | 0 |
| DQB1*0503 | 3 | 0.73 (0.29–1.82) | 0.497 | 1 | 0.540 | 0 |
| DQB1*0601 | 4 | 0.62 (0.29–1.30) | 0.205 | 1 | 0.113 | 49.81 |
| DQB1*0602 | 11 | 0.74 (0.64–0.86) | 0.0001 | 0.0034 | 0.187 | 27.00 |
| DQB1*0603 | 4 | 0.86 (0.68–1.08) | 0.194 | 1 | 0.848 | 0 |
| DQB1*0604 | 3 | 1.27 (0.59–2.74) | 0.545 | 1 | 0.428 | 0 |
| DRB1*01 | 4 | 0.73 (0.52–1.03) | 0.075 | 1 | 0.468 | 0 |
| DRB1*02 | 2 | 1.30 (0.96–1.75) | 0.087 | 1 | 0.314 | 1.49 |
| DRB1*03 | 4 | 1.37 (1.03–1.83) | 0.031 | 1 | 0.482 | 0 |
| DRB1*0301 | 5 | 3.16 (1.31–7.64) | 0.011 | 0.374 | 0.012 | 68.84 |
| DRB1*04 | 4 | 1.42 (0.97–2.08) | 0.071 | 1 | 0.118 | 48.95 |
| DRB1*0402 | 2 | 0.59 (0.21–1.67) | 0.319 | 1 | 0.452 | 0.00 |
| DRB1*0405 | 2 | 1.01 (0.12–8.40) | 0.994 | 1 | 0.149 | 51.87 |
| DRB1*07 | 4 | 1.28 (0.94–1.74) | 0.117 | 1 | 0.563 | 0 |
| DRB1*08 | 4 | 0.91 (0.47–1.77) | 0.781 | 1 | 0.750 | 0 |
| DRB1*09 | 4 | 1.11 (0.72–1.70) | 0.642 | 1 | 0.414 | 0 |
| DRB1*10 | 3 | 0.96 (0.29–3.22) | 0.949 | 1 | 0.301 | 16.82 |
| DRB1*11 | 3 | 0.81 (0.51–1.28) | 0.365 | 1 | 0.805 | 0 |
| DRB1*12 | 3 | 0.80 (0.51–1.26) | 0.342 | 1 | 0.513 | 0 |
| DRB1*13 | 2 | 0.84 (0.18–3.88) | 0.819 | 1 | 0.298 | 7.75 |
| DRB1*1302 | 3 | 3.37 (2.03–5.60) | 2.7 × 10−6 | 9.2 × 10−5 | 0.666 | 0 |
| DRB1*14 | 2 | 0.89 (0.43–1.83) | 0.750 | 1 | 0.896 | 0 |
| DRB1*15 | 2 | 0.60 (0.25–1.48) | 0.270 | 1 | 0.138 | 54.48 |
| DRB1*16 | 2 | 1.58 (0.63–3.92) | 0.328 | 1 | 0.279 | 14.82 |
OR odds ratio, CI confidence interval, P probability tested for overall effect, Adjusted P corrected p-values after Bonferroni correction, Ph probability tested for heterogeneity of included studies.