Figure 2. Efficacy of mCD4.1-PS1 formulated in HEC gel to prevent vaginal transmission of SHIV162P3 in macaques.

Plasma viral load in SHIV162P3 challenged macaques treated with placebo gel (A) or gel containing mCD4.1-PS1 at 144 μM (B) or 600 μM (C). Each gel formulation was applied into the vaginal vault of six naïve female cynomolgus macaques 1 hour before the challenge performed with ~10 AID₅₀ of SHIV162P3 inoculated in 50% human seminal plasma. Plasma viremia were measured regularly for 11 weeks by quantitative RT-PCR. The dotted line on the y-axis represents the 111 RNA copies/mL quantification limit.