Figure 5. Increased energy expenditure in FoxO1 KO^DAT mice.

(a) Cumulative food intake of male mice fed on HFD for 1 week. (b) Locomotor activity. (c) Temporal changes of O₂ consumption. (d) Average O₂ consumption. (e) Temporal changes of CO₂ production. (f) Average CO₂ production. (g) Heat generation between genotypes. (h) Rectal temperature of male and female mice measured at room temperature environment. ♂, male. ♀, female. NS, not significant. Data are expressed as mean±s.e.m. (*P<0.05, Student's t-test for bar graphs in h and two-way analysis of variance for multiple comparisons in a–g).