Table 1.
Causes of venous thrombosis
| Acquired | Genetic | Mixed | ||
|---|---|---|---|---|
| Medical | Drugs | Behavioural | ||
| Age | Oral contraceptives | Obesity | Non-0 blood group | High FVIII |
| Major surgery | Postmenopausal hormones | Long-haul travel | Antithrombin deficiency | High VWF |
| Neurosurgery | In vitro fertilization | Smoking | Protein C deficiency | High FIX |
| Orthopaedic surgery | Chemotherapy | No alcohol | Protein S deficiency | High FXI |
| Prostatectomy | Psychotropic drugs | No exercise | Factor V Leiden (rs6025) | High prothrombin |
| Malignancy | Thalidomide | Exercise (elderly) | Prothrombin 20210A (rs1799963) | dysfibrinogenaemia |
| Trauma | Corticosteroids | Coffee | fibrinogen 10034 T (rs2066865) | Low TFPI |
| Prolonged bed rest | Strenuous work (arm thrombosis) | factor XIII val34leu (rs5985) | High PCI | |
| Central venous catheter | SERPINC1 (rs2227589) | High fibrinogen | ||
| Plaster cast | FXI (rs2289252) | High TAFI | ||
| Myeoloproliferative disease | FXI (rs2036914) | Hypofibrinolysis | ||
| Heparin induced Thrombocytopenia | GP6 (rs1613662) | Hyperhomocysteinaemia | ||
| Hyperthyroid disease | FV (rs4524) | Hypercysteinaemia | ||
| Cushing syndrome | HIVEP1 (rs169713) | |||
| Arthroscopy | TSPAN15 (rs78707713) | |||
| Lupus anticoagulant | SLC44A2 (rs2288904) | |||
| ORM1 (rs150611042) | ||||
F factor, VWF von Willebrand factor, GP6 glycoprotein VI Platelet, TFPI tissue factor pathway inhibitor, TAFI thrombin activatable fibrinolysis inhibitor, PCI protein C inihibitor