Table 3.
Amino-acid residues of human progesterone receptor that were common among co-complex natural ligand, norethindrone (NET), and di-(2-ethylhexyl)phthalate (DEHP) and its five major metabolites, mono-(2-ethylhexyl)phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl)phthalate (5-OH-MEHP), mono-(2-ethyl-5-oxyhexyl)phthalate (5-oxo-MEHP), mono-(2-ethyl-5-carboxypentyl)phthalate (5-cx-MEPP), and mono-[2-(carboxymethyl)hexyl]phthalate (2-cx-MMHP)
| S. no | Interacting residue | S. no | Interacting residue |
|---|---|---|---|
| 1 | Leu-715a | 12 | Phe-778 |
| 2 | Leu-718 | 13 | Leu-797 |
| 3 | Asn-719 | 14 | Met-801 |
| 4 | Leu-721 | 15 | Leu-887 |
| 5 | Gly-722b | 16 | Tyr-890 |
| 6 | Gln-725 | 17 | Cys-891 |
| 7 | Met-756 | 18 | Thr-894a |
| 8 | Met-759 | 19 | Met-909 |
| 9 | Val-760 | ||
| 10 | Leu-763 | ||
| 11 | Arg-766 |
Amino-acid residues indicated by superscript a were not shared by MEHP and the residue indicated by superscript b was not shared by 5-OH-MEHP