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. 2016 Oct 4;14(Suppl 1):35. doi: 10.1186/s12959-016-0104-2

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Comparison of the hemostatic ability of wild-type mice and hemophilia B mice whose endogenous factor IX was exchanged for FIX_K5A. From: Cooley et al. Blood. 128:286. (2016). A mouse expressing FIX_K5A from its endogenous promoter was compared to a wild-type mouse using the saphenous vein bleeding model. The activity level of the FIX_K5A in the plasma of this mouse was slightly higher than that of the wild-type mouse. The mouse expressing FIX_K5A nevertheless has a bleeding diathesis