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. 2016 Oct 4;14(Suppl 1):35. doi: 10.1186/s12959-016-0104-2

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — An examination of the ability of FIX (BeneFIX) to effect hemostasis 7 days post-infusion, after the ability of a first injury to effect clotting has been exhausted. From: Cooley et al. Blood. 128:286. (2016). Seven days post-infusion, the right saphenous vein was injured and the number of times that re-clotting ensued was determined. After the first injury was unable to continue clotting, the contralateral vein was injured and hemostatic efficacy was again measured. Presumably, any residual plasma FIX would have been used up during the first injury had plasma FIX been required for clotting