Table 1.

Demographics and clinical characteristics by baseline statin use in the Women’s Health Initiative

Variables	Level	No baseline statin use (n = 118,201)	Baseline statin use (n = 10,474)
Trial membership	OS	68,294 (58 %)	6,500 (62 %)
	E-alone	4,631 (4 %)	516 (5 %)
	E + P trial	7,915 (7 %)	753 (7 %)
	DM	32,122 (27 %)	2,334 (22 %)
	E-alone/E + P trial + DM	5,239 (4 %)	371 (4 %)
Age group at screening	<50–59	39,446 (33 %)	1,865 (18 %)
	60–69	52,942 (45 %)	5,469 (52 %)
	70–79+	25,813 (22 %)	3,140 (30 %)
Age stratum at randomization or enrollment	50–54	15,967 (14 %)	565 (5 %)
	55–59	23,482 (20 %)	1,301 (12 %)
	60–69	52,936 (45 %)	5,466 (52 %)
	70–79	25,816 (22 %)	3,142 (30 %)
Ethnicity	Missing	286 (<1 %)	29 (<1 %)
	American Indian or Alaskan Native	449 (<1 %)	33 (<1 %)
	Asian or Pacific Islander	3,068 (3 %)	424 (4 %)
	Black or African–American	9,457 (8 %)	875 (8 %)
	Hispanic/Latino	3,461 (3 %)	274 (3 %)
	White (not of Hispanic origin)	100,194 (85 %)	8,719 (83 %)
	Other	1,286 (1 %)	120 (1 %)
Education	Missing	672 (1 %)	58 (1 %)
	None to some HS	4,733 (4 %)	608 (6 %)
	HS diploma/GED	19,365 (16 %)	2,199 (21 %)
	Vocational, training school, some college or associate degree	44,119 (37 %)	4,046 (39 %)
	College graduate or more	49,312 (42 %)	3,563 (34 %)
Smoking	Missing	1,411 (1 %)	134 (1 %)
	Never smoked	59,923 (51 %)	5,078 (48 %)
	Past smoker	49,887 (42 %)	4,670 (45 %)
	Current smoker	6,980 (6 %)	592 (6 %)
Alcohol use	Missing	779 (1 %)	63 (1 %)
	Nondrinker or past drinker	32,614 (28 %)	3,511 (34 %)
	<1 drink/month to<7 drinks per week	70,410 (60 %)	5,897 (56 %)
	7+ drinks a week	14,398 (12 %)	1,003 (10 %)
Physical activity	Missing	5,668 (5 %)	259 (2 %)
	None	16,676 (14 %)	1,454 (14 %)
	>0–3.75 MET-h/week	15,803 (13 %)	1,557 (15 %)
	3.75–8.75 MET-h/week	23,071 (20 %)	2,252 (22 %)
	8.75–17.5 MET-h/week	26,238 (22 %)	2,417 (23 %)
	≥17.5 MET-h/week	30,745 (26 %)	2,535 (24 %)
% Calories from fat	Missing	204 (<1 %)	15 (<1 %)
	<30 % calories from fat	42,688 (36 %)	4,634 (44 %)
	≥30 % calories from fat	75,309 (64 %)	5,825 (56 %)
BMI	Missing	1,003 (1 %)	87 (1 %)
	<25	43,150 (37 %)	2,614 (25 %)
	25–29	40,598 (34 %)	4,160 (40 %)
	≥30	33,450 (28 %)	3,613 (34 %)
Waist circumference	Missing	548 (<1 %)	52 (<1 %)
	≤88 cm	71,447 (60 %)	5,108 (49 %)
	>88 cm	46,206 (39 %)	5,314 (51 %)
Mammogram within 2 years of screening	Yes	107,682 (91 %)	9,754 (93 %)
	No	10,519 (9 %)	720 (7 %)
Gail risk of breast cancer	<1.67 %	68,434 (58 %)	5,429 (52 %)
	≤1.67 %	49,767 (42 %)	5,045 (48 %)
Female relative had breast cancer?	Missing	6,167 (5 %)	585 (6 %)
	No	90,935 (77 %)	8,005 (76 %)
	Yes	21,099 (18 %)	1,884 (18 %)
Age at menarche	Missing	409 (<1 %)	33 (<1 %)
	≤11	25,813 (22 %)	2,341 (22 %)
	12–13	65,509 (55 %)	5,768 (55 %)
	14+	26,470 (22 %)	2,332 (22 %)
Ever been pregnant?	Missing	276 (<1 %)	25 (<1 %)
	No	10,729 (9 %)	983 (9 %)
	Yes	107,196 (91 %)	9,466 (90 %)
Age at end of first full-term (at least 6 months) pregnancy	Missing	10,687 (9 %)	1,080 (10 %)
	Never pregnant	10,729 (9 %)	983 (9 %)
	Never had a term pregnancy	2,963 (3 %)	247 (2 %)
	<20	13,791 (12 %)	1,261 (12 %)
	20–29	71,220 (60 %)	6,146 (59 %)
	30+	8,811 (7 %)	757 (7 %)
Number of live births	Missing	691 (1 %)	61 (1 %)
	Never pregnant	10,729 (9 %)	983 (9 %)
	None	3,138 (3 %)	260 (2 %)
	1–2	41,301 (35 %)	3,481 (33 %)
	3+	62,342 (53 %)	5,689 (54 %)
Breast biopsy	Missing	6,363 (5 %)	322 (3 %)
	None	86,508 (73 %)	7,737 (74 %)
	1	17,711 (15 %)	1,648 (16 %)
	2+	7,619 (6 %)	767 (7 %)
Hysterectomy ever	Missing	63 (<1 %)	9 (<1 %)
	No	68,623 (58 %)	5,706 (54 %)
	Yes	49,515 (42 %)	4,759 (45 %)
Bilateral oophorectomy	Missing	2,492 (2 %)	273 (3 %)
	No	92,207 (78 %)	7,908 (76 %)
	Yes	23,502 (20 %)	2,293 (22 %)
Hormone use	Missing	98 (<1 %)	13 (<1 %)
	Never	46,433 (39 %)	4,591 (44 %)
	Past user	17,773 (15 %)	1,797 (17 %)
	Current user <5 years	15,067 (13 %)	1,122 (11 %)
	Current user 5–<10 years	13,424 (11 %)	915 (9 %)
	Current user ≥10 years	25,406 (21 %)	2,036 (19 %)
Current estrogen/progesterone use	Missing	98 (<1 %)	13 (<1 %)
	Never used either E-alone or E + P	46,433 (39 %)	4,591 (44 %)
	Past user of either E-alone or E + P	17,773 (15 %)	1,797 (17 %)
	Current user E-alone	29,911 (25 %)	2,522 (24 %)
	Current user E + P	23,986 (20 %)	1,551 (15 %)
Oral contraceptive use ever	Missing	2 (<1 %)	0 (<1 %)
	No	67,591 (57 %)	6,910 (66 %)
	Yes	50,608 (43 %)	3,564 (34 %)
Aspirin use	No	95,405 (81 %)	6,862 (66 %)
	Yes	22,796 (19 %)	3,612 (34 %)
NSAID use	No	80,283 (68 %)	5,757 (55 %)
	Yes	37,918 (32 %)	4,717 (45 %)
In general, would you say your health is…	Missing	639 (1 %)	65 (1 %)
	Excellent	21,413 (18 %)	817 (8 %)
	Very good	50,174 (42 %)	3,634 (35 %)
	Good	36,968 (31 %)	4,530 (43 %)
	Fair/poor	9,007 (8 %)	1,428 (14 %)
Diabetes ever	Missing	79 (<1 %)	11 (<1 %)
	No	111,944 (95 %)	9,266 (88 %)
	Yes	6,178 (5 %)	1,197 (11 %)
High cholesterol requiring pills ever	Missing	7,033 (6 %)	294 (3 %)
	No	103,091 (87 %)	348 (3 %)
	Yes	8,077 (7 %)	9,832 (94 %)
MI ever	Missing	54 (<1 %)	10 (<1 %)
	No	116,211 (98 %)	9,571 (91 %)
	Yes	1,936 (2 %)	893 (9 %)
Angina ever	Missing	732 (1 %)	80 (1 %)
	No	112,050 (95 %)	8,697 (83 %)
	Yes	5,419 (5 %)	1,697 (16 %)