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. Author manuscript; available in PMC: 2016 Oct 10.
Published in final edited form as: Biochem J. 2014 Aug 15;462(1):143–152. doi: 10.1042/BJ20140494

Figure 7. Model for induction of SR protein hyper-phosphorylated state by the CLK1 N-terminus.

Figure 7

N-terminus of CLK1 can interact with RS domain in both unphosphorylated and phosphorylated states, thereby inducing the hyper-phosphorylated states of SR proteins. In the absence of the N-terminus [CLK1(ΔN)], only hypo-phosphorylated state is possible.