Fig 1. Nasal mucociliary transport rate (NMTR) measurement with combined micro-CT-SPECT macroaggregated albumin (MAA)-Technetium 99 metaestable (Tc99m) in guinea pig.
A) MAA-Tc99m traveled distance at time 0. B) MAA-Tc99m traveled distance after 60 min of nasal administration. C) Bitter taste receptor agonists chloroquine, denatonium and saccharin were aerosolized during 10 min before nasal MAA-Tc99m administration and the distance traveled during 60 min was monitored. Nasal mucociliary transport rate was calculated as mm/min. Representative images of n = 9 guinea pig per condition are showed. Colorimetric intensity scale adjusted for all images is shown. Results are expressed as mean ± SD. One-way repeated measures analysis of variance (ANOVA): P<0.001. Post hoc Bonferroni test: *P<0.001 compared with controls.