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. 2016 Oct 10;11(10):e0164193. doi: 10.1371/journal.pone.0164193

Fig 4. Early initiation of sirolimus reduces the increase in total kidney volume in LPK rats.

Fig 4

A and B. Representative MR images of the experimental groups at weeks 6 and 10. An in-plane resolution of approximately 0.28–0.39mm and an effective through-plane resolution of 0.8mm for both the coronal and axial image sets within acceptable scan times (coronal: 6min 44sec and axial: 5min 26sec) was achieved. Signal-to noise ratio was sufficient to enable accurate segmentation and volume calculation using 3D SLICER. Anatomical detail of the kidneys was well visualized. Images from the 3D FIESTA sequence are shown. C. Graph showing total kidney volume (TKV) in the experimental groups at weeks 4 and 10. The TKV increased by ~2.4 times in both the Lewis+vehicle and LPK+sirolimus groups from weeks 4 to 10. In contrast in the LPK+vehicle group increased by 11.6 times over the same period. Data expressed as mean±SD; At week 4, Lewis+vehicle: n = 1; LPK+vehicle:; LPK+sirolimus:; n = 3–4 per group) and at week 10, Lewis+vehicle n = 3; Lewis+sirolimus n = 3; LPK+vehicle n = 6; LPK+sirolimus.