Table 1. Renal function, serum cholesterol and whole blood sirolimus levels in Lewis and LPK rats at week 10 in the early treatment study (Study 2).

Data are expressed as mean±SD; Abbreviations: CrCl, creatinine clearance; *P<0.05 when compared to Lewis+vehicle; ND, not determined.

	Lewis+vehicle	Lewis+sirolimus	LPK+vehicle	LPK+sirolimus
	N = 4	N = 4	N = 9	N = 9
Creatinine (μmol/L)	29±5	32±3	49±9*	53±24*
Urea (mmol/L)	5.4±1.1	5.0±0.7	15.6±4.6	13.1±9.3
CrCl (μL/min/cm2)	6.6±0.8	3.8±1.6*	2.7±0.9*	2.9±1.2*
Albumin (g/dL)	30±2	29±1	27±3	31±5
Cholesterol (mmol/L)	1.5±0.2	2.3±0.3*	2.6±0.4*	3.2±0.5*
Sirolimus (ng/ml)	ND	11.8±6.2	ND	15.7±7.5