Table 1. Characteristics of patients with juvenile idiopathic arthritis associated uveitis at the age of 18, 22 and 30 years.
| < 1990 | ≥ 1990 | |||||||
|---|---|---|---|---|---|---|---|---|
| Characteristics | Total | 18 years | 22 years | 30 years | 18 years | 22 years | 30 years | |
| Total no. patients | 67 | 7 | 8 | 13 | 45 | 18 | 0 | |
| Total no. eyes | 129 | 14 | 16 | 26 | 86 | 36 | NA | |
| Bilateral uveitis no. patients (%) | 62 (93) | 7 (100) | 8 (100) | 13 (100) | 41 (91) | 18 (100) | NA | |
| Female, no. patients (%) | 50 (75) | 6 (86) | 7 (88) | 12 (92) | 30 (67) | 13 (72) | NA | |
| Median age (y) at onset uveitis (range) | 5.2 (1.2–14.6) | 4.1 (3.0–9.3) | 4.5 (3.0–9.3) | 4.9 (3.0–9.3) | 5.3 (2.6–14.6) | 5.2 (2.6–12.7) | NA | |
| Median age (y) at onset arthritis (range) | 3.5 (0.8–16.1) | 3.0 (0.8–7.4) | 2.9 (0.8–7.4) | 3.0 (0.8–7.4) | 3.8 (0.9–16.1) | 4.7 (1.0–12.7) | NA | |
| Interval (y) arthritis-uveitis, median (range) | 0.5 (-9.8–13.3) | 0.7 (-3.4–6.5) | 1.6 (-3.4–6.5) | 0.7 (-3.4–6.5) | 0.4 (-9.8–13.3) | 0.5 (-6.7–6.0) | NA | |
| Median duration (y) of uveitis (range) | NA | 13.9 (8.7–15.0) | 17.5 (12.7–19.0) | 25.1 (20.7–27.0) | 12.7 (3.4–15.4) | 16.9 (9.3–19.4) | NA | |
| Arthritis onset before uveitis, no. patients (%) | 48 (74) | 5 (83) | 6 (86) | 9 (82) | 30 (67) | 13 (72) | NA | |
| JIA subtype, no. patients (%) | Oligoarthritis | 35 (52) | 4 (57) | 4 (50) | 5 (38) | 28 (62) | 9 (50) | NA |
| Extended oligoarthritis | 9 (13) | 0 (0) | 0 (0) | 1 (8) | 7 (16) | 5 (28) | NA | |
| Polyarthritis | 15 (22) | 1 (14) | 1 (13) | 2 (16) | 8 (18) | 4 (22) | NA | |
| Unknown | 8 (12) | 2 (29) | 3 (37) | 5 (38) | 2 (4) | 0 (0) | NA | |
| ANA, no. patients | Total | 64 | 7 | 8 | 12 | 44 | 18 | NA |
| Positive (%) | 52 (81) | 6 (86) | 7 (88) | 11 (92) | 37 (84) | 15 (83) | NA | |
| HLA-B27, no. Patients | Total | 28 | 1 | 2 | 5 | 18 | 8 | NA |
| Positive (%) | 5 (18) | 0 (0) | 0 (0) | 1 (20) | 3 (17) | 0 (0) | NA |
JIA = juvenile idiopathic arthritis; ANA = antinuclear antibodies; HLA-B27 = human leukocyte antigen B27; NA = not applicable. Per age-group statistical analyses were performed comparing patients with an uveitis diagnosis before (<) or after (≥) 1990 by the Fisher exact test and Mann-Whitney U test. No statistically significant differences were found. In the group with an uveitis diagnosis <1990, more data were available at age 30 years than at age 18 or 22 years. Because of the retrospective character of the study, more data were missing at the latter two time-points.