Table 2. Juvenile idiopathic arthritis associated uveitis in adulthood, a literature overview.
| Author | Nr patients | Mean/median age years (range) | Follow-up | Visual acuity | Definition active uveitis | Uveitis activity | Complications, treatment |
|---|---|---|---|---|---|---|---|
| Packham et al 2002[13] | 54 | 35 (19–78) (= age of total JIA group with 246 patients) | Situation at the end of follow-up. | NA | Not defined | NA | 66% of the patients had glaucoma during follow-up, 55% had cataract, 69% had had eye-surgery (not specifically during adulthood). |
| Zak et al 2003[14] | 12 | 32 (22–49) | Situation at the end of follow-up. | Studied visual field outcomes.a 1 patient with bilateral severe visual field loss. 1 patient with unilateral VA <0.02. | Not defined | NA | Almost all patients had anterior segment findings as sequelae. |
| Ozdal et al 2005[15] | 18 (30 eyes) | 30 (18–48) | Situation at the end of follow-up. Minimum follow-up = 2 years. | 9 patients (50%) had a BCVA <20/150 of at least one eye. | Presence of cells or keratic precipitates, with or without flare. | 19 (63%) of the eyes had active uveitis. | 3 eyes with phtisis. 73% (22 eyes) had cataract extraction, 4 eyes (13%) had glaucoma surgery by drainage device or trabeculectomy (not specifically during adulthood). 11 patients (61.1%) required the use of a systemic immunosuppresive agent. 16/18 patients were on topical steroids. |
| Kotaniemi et al 2005[16] | 19 | 24 (22–26) | One consult for evaluation. | 100% binocular normal BCVA, 3 patients had unilateral BCVA <0.1. | Use of topical corticosteroids and/or at least 3 cells in the anterior chamber. | 8 patients had active uveitis. | 4 patients had glaucoma, 5 had cataract. 53% of the patients were on systemic IMT. 10/19 patients used treatment (systemic and/or topical). |
| Camuglia et al 2009[17] | 17 | 30 (21–43) | Situation at the end of follow-up. | 20% of the eyes had visual loss up to 6/12, 13.3% of the eyes had visual loss up to 6/60. | Not defined | NA | 53% of the patients (9 patients, 13 eyes) had new complications of cataract or glaucoma after their 16th birthday. Two eyes had glaucoma surgery and 10 eyes had cataract surgery after the age of 16. 30% of the patients had synechiae during their uveitis course. 10/17 patients used systemic treatment, all patients had topical treatment. |
| Skarin et al 2009[35] | 55 | NA | Follow-up at 24 years (range 18–46) after uveitis onset. | NA | Not defined | 49% of the 55 patients had signs of active uveitis or were receiving topical corticosteroids. | 12 patients (33%) had glaucoma, 28 patients (78%) had cataract. |
| Oray et al 2016[18] | 77 (135 eyes) | 29.7 (±11) | Situation at the end of follow-up. | 37 eyes (28%) had a visual acuity of ≤20/50. 20 eyes (15%) had a visual acuity of ≤20/200. | ≥0.5+ cells in the anterior chamber. | 78 eyes (58%). | Ocular surgery in 68 eyes. 13 patients (17%) were treated with conventional IMT (e.g. MTX), 52 patients (68%) were treated with biologicals. At least one complication in 95 eyes (72%). |
This table describes all previous literature on the course of juvenile idiopathic arthritis associated uveitis in adulthood.
aThis was the only study which described visual field outcomes.
NA = not applicable; IMT = immunomodulatory treatment; MTX = Methotrexate.